Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer.

Sen, Triparna

Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer. [electronic resource] - Cancer discovery 05 2019 - 646-661 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2159-8290

10.1158/2159-8290.CD-18-1020 doi


Animals
Apoptosis--drug effects
B7-H1 Antigen--antagonists & inhibitors
CD8-Positive T-Lymphocytes--drug effects
Cell Proliferation--drug effects
DNA Damage
Female
Humans
Interferon Regulatory Factor-3--genetics
Lung Neoplasms--drug therapy
Lymphocyte Activation--drug effects
Membrane Proteins--genetics
Mice
Mice, Nude
Phthalazines--pharmacology
Piperazines--pharmacology
Poly(ADP-ribose) Polymerase Inhibitors--pharmacology
Protein Kinase Inhibitors--pharmacology
Protein Serine-Threonine Kinases--genetics
Pyrazines--pharmacology
Pyrazoles--pharmacology
Random Allocation
Small Cell Lung Carcinoma--drug therapy
T-Lymphocytes, Cytotoxic--drug effects
Tumor Cells, Cultured
Xenograft Model Antitumor Assays