PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27
Tuo, Lin
PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27 [electronic resource] - Journal of experimental & clinical cancer research : CR Feb 2019 - 50 p. digital
Publication Type: Journal Article
1756-9966
10.1186/s13046-019-1029-y doi
AMP-Activated Protein Kinases--genetics
Animals
Calcium-Binding Proteins--metabolism
Carcinoma, Hepatocellular--drug therapy
Cell Line, Tumor
Cell Proliferation--drug effects
Cyclin-Dependent Kinases--metabolism
Down-Regulation
E2F Transcription Factors--metabolism
G1 Phase Cell Cycle Checkpoints--drug effects
Gene Knockdown Techniques
Glucose--metabolism
Humans
Hypoglycemic Agents--pharmacology
Intracellular Signaling Peptides and Proteins--genetics
Liver Neoplasms--drug therapy
Male
Metformin--pharmacology
Mice
Phosphoenolpyruvate Carboxykinase (GTP)--genetics
Up-Regulation
Xenograft Model Antitumor Assays
PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27 [electronic resource] - Journal of experimental & clinical cancer research : CR Feb 2019 - 50 p. digital
Publication Type: Journal Article
1756-9966
10.1186/s13046-019-1029-y doi
AMP-Activated Protein Kinases--genetics
Animals
Calcium-Binding Proteins--metabolism
Carcinoma, Hepatocellular--drug therapy
Cell Line, Tumor
Cell Proliferation--drug effects
Cyclin-Dependent Kinases--metabolism
Down-Regulation
E2F Transcription Factors--metabolism
G1 Phase Cell Cycle Checkpoints--drug effects
Gene Knockdown Techniques
Glucose--metabolism
Humans
Hypoglycemic Agents--pharmacology
Intracellular Signaling Peptides and Proteins--genetics
Liver Neoplasms--drug therapy
Male
Metformin--pharmacology
Mice
Phosphoenolpyruvate Carboxykinase (GTP)--genetics
Up-Regulation
Xenograft Model Antitumor Assays