Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner.

Huang, Dong-Dong

Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner. [electronic resource] - Experimental gerontology 05 2019 - 61-73 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1873-6815

10.1016/j.exger.2019.01.022 doi


Aging--genetics
Animals
Disease Models, Animal
Frailty--etiology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondria, Muscle--pathology
Mitochondrial Dynamics
Muscle, Skeletal--pathology
NF-E2-Related Factor 2--deficiency
Organelle Biogenesis
RNA, Messenger--genetics
Sarcopenia--etiology