Novel small molecule IL-6 inhibitor suppresses autoreactive Th17 development and promotes T
Aqel, S I
Novel small molecule IL-6 inhibitor suppresses autoreactive Th17 development and promotes T [electronic resource] - Clinical and experimental immunology 05 2019 - 215-225 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1365-2249
10.1111/cei.13258 doi
Adoptive Transfer--methods
Animals
CD4-Positive T-Lymphocytes--drug effects
Encephalomyelitis, Autoimmune, Experimental--drug therapy
Humans
Interleukin-6--antagonists & inhibitors
Mice
Mice, Inbred C57BL
Mice, Transgenic
Multiple Sclerosis--drug therapy
Myelin Sheath--metabolism
STAT3 Transcription Factor--metabolism
Signal Transduction--drug effects
Small Molecule Libraries--pharmacology
T-Lymphocytes, Regulatory--drug effects
Th17 Cells--drug effects
Novel small molecule IL-6 inhibitor suppresses autoreactive Th17 development and promotes T [electronic resource] - Clinical and experimental immunology 05 2019 - 215-225 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1365-2249
10.1111/cei.13258 doi
Adoptive Transfer--methods
Animals
CD4-Positive T-Lymphocytes--drug effects
Encephalomyelitis, Autoimmune, Experimental--drug therapy
Humans
Interleukin-6--antagonists & inhibitors
Mice
Mice, Inbred C57BL
Mice, Transgenic
Multiple Sclerosis--drug therapy
Myelin Sheath--metabolism
STAT3 Transcription Factor--metabolism
Signal Transduction--drug effects
Small Molecule Libraries--pharmacology
T-Lymphocytes, Regulatory--drug effects
Th17 Cells--drug effects