Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.

Nguyen, Duy

Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. [electronic resource] - Journal of medicinal chemistry 01 2019 - 928-940 p. digital

Publication Type: Journal Article

1520-4804

10.1021/acs.jmedchem.8b01606 doi


Apoptosis--drug effects
Binding Sites
Cell Differentiation--drug effects
Cell Line
Cell Proliferation--drug effects
Crystallography, X-Ray
Drug Evaluation, Preclinical
Half-Life
Humans
Mitogen-Activated Protein Kinase 7--antagonists & inhibitors
Molecular Docking Simulation
Protein Kinase Inhibitors--chemistry
Protein Structure, Tertiary
Pyridines--chemistry
Pyrimidines--chemistry
Signal Transduction--drug effects
Structure-Activity Relationship
Transcription, Genetic--drug effects