Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease.
Litvinchuk, Alexandra
Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease. [electronic resource] - Neuron 12 2018 - 1337-1353.e5 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1097-4199
10.1016/j.neuron.2018.10.031 doi
Adult
Aged
Aged, 80 and over
Alzheimer Disease--complications
Animals
Brain--pathology
Calcium-Binding Proteins
Cognition Disorders--etiology
Complement C3a--genetics
Cytokines--metabolism
DNA-Binding Proteins--metabolism
Disease Models, Animal
Evoked Potentials--physiology
Female
Gene Regulatory Networks--physiology
Humans
Male
Mice
Mice, Transgenic
Microfilament Proteins
Middle Aged
Receptors, Complement--genetics
Signal Transduction--drug effects
Tauopathies--complications
Up-Regulation--physiology
tau Proteins--genetics
Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease. [electronic resource] - Neuron 12 2018 - 1337-1353.e5 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1097-4199
10.1016/j.neuron.2018.10.031 doi
Adult
Aged
Aged, 80 and over
Alzheimer Disease--complications
Animals
Brain--pathology
Calcium-Binding Proteins
Cognition Disorders--etiology
Complement C3a--genetics
Cytokines--metabolism
DNA-Binding Proteins--metabolism
Disease Models, Animal
Evoked Potentials--physiology
Female
Gene Regulatory Networks--physiology
Humans
Male
Mice
Mice, Transgenic
Microfilament Proteins
Middle Aged
Receptors, Complement--genetics
Signal Transduction--drug effects
Tauopathies--complications
Up-Regulation--physiology
tau Proteins--genetics