Identification of a cellularly active SIRT6 allosteric activator.

Huang, Zhimin

Identification of a cellularly active SIRT6 allosteric activator. [electronic resource] - Nature chemical biology 12 2018 - 1118-1126 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1552-4469

10.1038/s41589-018-0150-0 doi


Allosteric Regulation
Allosteric Site
Animals
Antineoplastic Agents--pharmacology
Benzoates--pharmacology
Carcinoma, Hepatocellular--drug therapy
Cell Line
Cell Line, Tumor
Crystallography, X-Ray
Female
High-Throughput Screening Assays--methods
Humans
Liver Neoplasms--drug therapy
Mice, Inbred BALB C
Molecular Dynamics Simulation
Molecular Targeted Therapy
Sirtuins--chemistry
Sulfur Compounds--pharmacology
Xenograft Model Antitumor Assays