Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension.

Krishnan, Shalini M

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension. [electronic resource] - Cardiovascular research 03 2019 - 776-787 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1755-3245

10.1093/cvr/cvy252 doi


Albuminuria--etiology
Animals
Anti-Inflammatory Agents--pharmacology
Antihypertensive Agents--pharmacology
Blood Pressure--drug effects
Chemotaxis, Leukocyte--drug effects
Collagen--metabolism
Desoxycorticosterone Acetate
Disease Models, Animal
Fibrosis
Furans--pharmacology
Heterocyclic Compounds, 4 or More Rings
Hypertension--etiology
Indenes
Inflammation Mediators--metabolism
Kidney--drug effects
Macrophages--drug effects
Male
Mice, Inbred C57BL
NLR Family, Pyrin Domain-Containing 3 Protein--antagonists & inhibitors
Nephrectomy
Signal Transduction
Sodium Chloride, Dietary
Sulfonamides--pharmacology
Sulfones
T-Lymphocyte Subsets--drug effects