Synthesis of Gemcitabine-Threonine Amide Prodrug Effective on Pancreatic Cancer Cells with Improved Pharmacokinetic Properties.

Hong, Sungwoo

Synthesis of Gemcitabine-Threonine Amide Prodrug Effective on Pancreatic Cancer Cells with Improved Pharmacokinetic Properties. [electronic resource] - Molecules (Basel, Switzerland) Oct 2018

Publication Type: Journal Article

1420-3049

10.3390/molecules23102608 doi


Amino Acids
Animals
Antineoplastic Agents--chemical synthesis
Cell Line, Tumor
Chemistry Techniques, Synthetic
Chromatography, Liquid
Chromatography, Thin Layer
Deoxycytidine--analogs & derivatives
Disease Models, Animal
Drug Monitoring
Drug Stability
Humans
Magnetic Resonance Spectroscopy
Pancreatic Neoplasms--drug therapy
Prodrugs--chemical synthesis
Tandem Mass Spectrometry
Threonine--chemistry
Xenograft Model Antitumor Assays
Gemcitabine