A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice.

Zhang, Yifan

A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice. [electronic resource] - Kidney international 09 2018 - 524-535 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1523-1755

10.1016/j.kint.2018.05.002 doi


Acute Kidney Injury--drug therapy
Angiogenesis Inhibitors--pharmacology
Animals
Blood Glucose--metabolism
Capillaries--drug effects
Disease Models, Animal
Drug Evaluation, Preclinical
Fibrosis
Gene Knockdown Techniques
Glucose Transporter Type 2--genetics
Humans
Kidney Tubules, Proximal--blood supply
Male
Mice
Mice, Inbred C57BL
Receptors, Vascular Endothelial Growth Factor--antagonists & inhibitors
Reperfusion Injury--complications
Sodium-Glucose Transporter 2--metabolism
Sodium-Glucose Transporter 2 Inhibitors--pharmacology
Sorbitol--analogs & derivatives
Sunitinib--pharmacology
Treatment Outcome
Vascular Endothelial Growth Factor A--metabolism