Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader.

Bapiro, Tashinga E

Complete Substrate Inhibition of Cytochrome P450 2C8 by AZD9496, an Oral Selective Estrogen Receptor Degrader. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals 09 2018 - 1268-1276 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1521-009X

10.1124/dmd.118.081539 doi


Administration, Oral
Cinnamates--metabolism
Cytochrome P-450 CYP2C8--metabolism
Cytochrome P-450 CYP2C8 Inhibitors--metabolism
Dose-Response Relationship, Drug
Female
Humans
Indoles--metabolism
Male
Microsomes, Liver--drug effects
Receptors, Estrogen--antagonists & inhibitors
Substrate Specificity--drug effects