Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity.

Wang, David

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. [electronic resource] - Cell reports 06 2018 - 3262-3274 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2211-1247

10.1016/j.celrep.2018.05.050 doi


Animals
CD4-Positive T-Lymphocytes--cytology
CD8-Positive T-Lymphocytes--cytology
Cell Line, Tumor
Enhancer of Zeste Homolog 2 Protein--deficiency
Forkhead Transcription Factors--metabolism
Humans
Interferon-gamma--metabolism
Lymphocytes, Tumor-Infiltrating--cytology
Mice
Mice, Inbred C57BL
Mice, Knockout
Neoplasms--immunology
T-Lymphocytes, Regulatory--cytology
Tumor Microenvironment
Tumor Necrosis Factor-alpha--metabolism