Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention.

Baptiste, Beverly A

Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention. [electronic resource] - Free radical biology & medicine 08 2018 - 149-162 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

1873-4596

10.1016/j.freeradbiomed.2018.05.094 doi


A549 Cells
Animals
Cells, Cultured
DNA Damage
DNA Glycosylases--genetics
DNA Repair
DNA, Mitochondrial--genetics
Fibroblasts--cytology
Herbicides--adverse effects
Humans
Mice
Mice, Knockout
Mitochondria--drug effects
Mutation
Oxidation-Reduction
Oxidative Stress--drug effects
Paraquat--adverse effects
Reactive Oxygen Species--metabolism
Serine--genetics
Small Molecule Libraries--pharmacology