Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor.
Wang, Zhuo
Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor. [electronic resource] - Cell death & disease 04 2018 - 613 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-4889
10.1038/s41419-018-0573-2 doi
Angiotensin II
Animals
Collagen--metabolism
Dipeptides--metabolism
Disease Models, Animal
Fibrosis
GTP-Binding Proteins--antagonists & inhibitors
Human Umbilical Vein Endothelial Cells--drug effects
Humans
Mice
Myocardium--pathology
Myofibroblasts--drug effects
Protein Glutamine gamma Glutamyltransferase 2
Small Molecule Libraries--pharmacology
Transforming Growth Factor beta1--pharmacology
Transglutaminases--antagonists & inhibitors
Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor. [electronic resource] - Cell death & disease 04 2018 - 613 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-4889
10.1038/s41419-018-0573-2 doi
Angiotensin II
Animals
Collagen--metabolism
Dipeptides--metabolism
Disease Models, Animal
Fibrosis
GTP-Binding Proteins--antagonists & inhibitors
Human Umbilical Vein Endothelial Cells--drug effects
Humans
Mice
Myocardium--pathology
Myofibroblasts--drug effects
Protein Glutamine gamma Glutamyltransferase 2
Small Molecule Libraries--pharmacology
Transforming Growth Factor beta1--pharmacology
Transglutaminases--antagonists & inhibitors