RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation.

Bustos, Francisco

RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation. [electronic resource] - Cell reports 05 2018 - 1599-1611 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2211-1247

10.1016/j.celrep.2018.04.022 doi


Animals
Biocatalysis
CRISPR-Cas Systems
Cell Differentiation--genetics
Cell Nucleus--metabolism
Gene Silencing
Genes, X-Linked
Humans
Intellectual Disability--genetics
Male
Mice
Mutation--genetics
Neural Stem Cells--metabolism
Neurons--metabolism
Protein Multimerization
Protein Stability
Proteolysis
Substrate Specificity
Ubiquitin--metabolism
Ubiquitin-Protein Ligases--genetics
Ubiquitination