GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.

Lozovaya, N

GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease. [electronic resource] - Nature communications 04 2018 - 1422 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

2041-1723

10.1038/s41467-018-03802-y doi


Acetylcholine--metabolism
Action Potentials--drug effects
Animals
Bumetanide--pharmacology
Chlorides--metabolism
Cholinergic Agents--metabolism
Cholinergic Neurons--drug effects
Corpus Striatum--drug effects
Dopamine--deficiency
Gene Expression Regulation
Glutamate Decarboxylase--genetics
Humans
Inhibitory Postsynaptic Potentials--drug effects
Interneurons--drug effects
Ion Transport
LIM-Homeodomain Proteins--genetics
Mice
Mice, Transgenic
Nerve Tissue Proteins--genetics
Neuronal Plasticity--drug effects
Parkinson Disease, Secondary--genetics
Patch-Clamp Techniques
Sodium Potassium Chloride Symporter Inhibitors--pharmacology
Solute Carrier Family 12, Member 2--genetics
Transcription Factors--genetics
Vesicular Inhibitory Amino Acid Transport Proteins--genetics
gamma-Aminobutyric Acid--metabolism