Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism.

Fiorillo, Marco

Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism. [electronic resource] - Biochimica et biophysica acta. Bioenergetics 09 2018 - 984-996 p. digital

Publication Type: Journal Article

0005-2728

10.1016/j.bbabio.2018.03.018 doi


Apoptosis--drug effects
Biological Products--pharmacology
Biomarkers, Tumor--metabolism
Breast Neoplasms--drug therapy
Cell Proliferation--drug effects
Cells, Cultured
Female
Fibroblasts--cytology
Gene Expression Regulation, Neoplastic--drug effects
Humans
Hydroxymethylglutaryl CoA Reductases--metabolism
Mevalonic Acid--metabolism
Mitochondria--drug effects
Neoplasm Metastasis
Neoplastic Stem Cells--drug effects
Plant Oils--chemistry
Prognosis
Signal Transduction--drug effects
Survival Rate
rho-Specific Guanine Nucleotide Dissociation Inhibitors--metabolism