Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.

Dias Viegas, Flávia Pereira

Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates. [electronic resource] - European journal of medicinal chemistry Mar 2018 - 48-65 p. digital

Publication Type: Journal Article

1768-3254

10.1016/j.ejmech.2018.01.066 doi


Acetylcholinesterase--metabolism
Alzheimer Disease--drug therapy
Anti-Inflammatory Agents, Non-Steroidal--chemical synthesis
Cholinesterase Inhibitors--chemical synthesis
Donepezil
Dose-Response Relationship, Drug
Drug Discovery
Hep G2 Cells
Humans
Hydrazones--chemistry
Indans--chemical synthesis
Models, Molecular
Molecular Structure
Neuroprotective Agents--chemical synthesis
Piperidines--chemical synthesis
Structure-Activity Relationship