Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation.
Taban, Ismail M
Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation. [electronic resource] - Journal of medicinal chemistry 12 2017 - 10257-10267 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/acs.jmedchem.7b01562 doi
Antitubercular Agents--chemistry
Bacterial Proteins--antagonists & inhibitors
Binding Sites
Crystallography, X-Ray
Cytochrome P-450 Enzyme Inhibitors--chemical synthesis
Cytochrome P-450 Enzyme System--chemistry
Drug Evaluation, Preclinical--methods
Microbial Sensitivity Tests
Molecular Docking Simulation
Mycobacterium tuberculosis--drug effects
Pyrazoles--chemistry
Small Molecule Libraries--chemistry
Spectrophotometry, Ultraviolet
Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation. [electronic resource] - Journal of medicinal chemistry 12 2017 - 10257-10267 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/acs.jmedchem.7b01562 doi
Antitubercular Agents--chemistry
Bacterial Proteins--antagonists & inhibitors
Binding Sites
Crystallography, X-Ray
Cytochrome P-450 Enzyme Inhibitors--chemical synthesis
Cytochrome P-450 Enzyme System--chemistry
Drug Evaluation, Preclinical--methods
Microbial Sensitivity Tests
Molecular Docking Simulation
Mycobacterium tuberculosis--drug effects
Pyrazoles--chemistry
Small Molecule Libraries--chemistry
Spectrophotometry, Ultraviolet