SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT-receptor complex.

Zhao, S-J

SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT-receptor complex. [electronic resource] - Oncogene 02 2018 - 1049-1061 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1476-5594

10.1038/onc.2017.403 doi


Animals
Apoptosis
Biomarkers, Tumor--genetics
Bone Neoplasms--genetics
Calcium-Binding Proteins--genetics
Cell Movement
Cell Proliferation
Chemokine CCL5--genetics
Extracellular Matrix Proteins--genetics
Frizzled Receptors--genetics
Gene Expression Regulation, Neoplastic
Humans
Low Density Lipoprotein Receptor-Related Protein-5--genetics
Low Density Lipoprotein Receptor-Related Protein-6--genetics
Lung Neoplasms--genetics
Macrophages--metabolism
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasm Invasiveness
Osteosarcoma--genetics
Tumor Cells, Cultured
Wnt Proteins--genetics
Xenograft Model Antitumor Assays
beta Catenin--genetics