Low copy numbers of complement C4 and homozygous deficiency of C4A may predispose to severe disease and earlier disease onset in patients with systemic lupus erythematosus.

Jüptner, M

Low copy numbers of complement C4 and homozygous deficiency of C4A may predispose to severe disease and earlier disease onset in patients with systemic lupus erythematosus. [electronic resource] - Lupus Apr 2018 - 600-609 p. digital

Publication Type: Journal Article

1477-0962

10.1177/0961203317735187 doi


Adult
Aged
Case-Control Studies
Chi-Square Distribution
Complement C4a--deficiency
DNA Copy Number Variations
Drug Therapy, Combination
Female
Gene Deletion
Gene Dosage
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Germany
HLA-DRB1 Chains--genetics
Homozygote
Humans
Immunosuppressive Agents--therapeutic use
Logistic Models
Lupus Erythematosus, Systemic--diagnosis
Male
Middle Aged
Odds Ratio
Phenotype
Polymorphism, Single Nucleotide
Prognosis
Risk Factors
Severity of Illness Index
Time Factors
Young Adult