Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development.
Tang, Qian
Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development. [electronic resource] - Cell death & disease 10 2017 - e3081 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-4889
10.1038/cddis.2017.453 doi
Animals
Apoptosis--drug effects
Autophagy--drug effects
Chondrocytes--drug effects
DNA Damage--drug effects
Endoplasmic Reticulum Stress--drug effects
Humans
Membrane Proteins--genetics
Mice
Mitochondrial Proteins--genetics
Osteoarthritis--drug therapy
Oxidative Stress--drug effects
Phosphoprotein Phosphatases--genetics
RNA, Small Interfering--administration & dosage
RNA-Binding Proteins--genetics
Trehalose--administration & dosage
tert-Butylhydroperoxide--toxicity
Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development. [electronic resource] - Cell death & disease 10 2017 - e3081 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-4889
10.1038/cddis.2017.453 doi
Animals
Apoptosis--drug effects
Autophagy--drug effects
Chondrocytes--drug effects
DNA Damage--drug effects
Endoplasmic Reticulum Stress--drug effects
Humans
Membrane Proteins--genetics
Mice
Mitochondrial Proteins--genetics
Osteoarthritis--drug therapy
Oxidative Stress--drug effects
Phosphoprotein Phosphatases--genetics
RNA, Small Interfering--administration & dosage
RNA-Binding Proteins--genetics
Trehalose--administration & dosage
tert-Butylhydroperoxide--toxicity