Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway.

Chen, Ming-Liang

Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway. [electronic resource] - Journal of the American Heart Association 09 2017

Publication Type: Journal Article

2047-9980

10.1161/JAHA.117.006347 doi


Animals
Antioxidants--pharmacology
Apoptosis Regulatory Proteins--metabolism
Atherosclerosis--chemically induced
Cells, Cultured
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Genetic Predisposition to Disease
Human Umbilical Vein Endothelial Cells--drug effects
Humans
Inflammasomes--agonists
Inflammation Mediators--metabolism
Methylamines--toxicity
Mice, 129 Strain
Mice, Knockout, ApoE
Mitochondria--drug effects
NLR Family, Pyrin Domain-Containing 3 Protein--agonists
Phenotype
RNA Interference
Reactive Oxygen Species--metabolism
Signal Transduction--drug effects
Sirtuin 3--deficiency
Superoxide Dismutase--metabolism
Time Factors
Transfection
Vasculitis--chemically induced