Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B.
Wroblewski, M
Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B. [electronic resource] - Nature communications 08 2017 - 269 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-1723
10.1038/s41467-017-00327-8 doi
Angiogenesis Inhibitors--pharmacology
Animals
Anti-Asthmatic Agents--pharmacology
Cell Line, Tumor
Cell Proliferation--drug effects
Cromolyn Sodium--pharmacology
Endothelial Cells--drug effects
Extracellular Matrix--drug effects
Fibroblast Growth Factor 1--drug effects
Fibroblast Growth Factor 2--drug effects
Granulocyte-Macrophage Colony-Stimulating Factor--drug effects
Granzymes--metabolism
Human Umbilical Vein Endothelial Cells
Laminin--metabolism
Mast Cells--drug effects
Mice
Neoplasms--blood supply
Neovascularization, Pathologic--metabolism
Vascular Endothelial Growth Factor A--drug effects
Vascular Endothelial Growth Factor Receptor-2--drug effects
Vitronectin--metabolism
Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B. [electronic resource] - Nature communications 08 2017 - 269 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-1723
10.1038/s41467-017-00327-8 doi
Angiogenesis Inhibitors--pharmacology
Animals
Anti-Asthmatic Agents--pharmacology
Cell Line, Tumor
Cell Proliferation--drug effects
Cromolyn Sodium--pharmacology
Endothelial Cells--drug effects
Extracellular Matrix--drug effects
Fibroblast Growth Factor 1--drug effects
Fibroblast Growth Factor 2--drug effects
Granulocyte-Macrophage Colony-Stimulating Factor--drug effects
Granzymes--metabolism
Human Umbilical Vein Endothelial Cells
Laminin--metabolism
Mast Cells--drug effects
Mice
Neoplasms--blood supply
Neovascularization, Pathologic--metabolism
Vascular Endothelial Growth Factor A--drug effects
Vascular Endothelial Growth Factor Receptor-2--drug effects
Vitronectin--metabolism