Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest.
Sarin, Navin
Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest. [electronic resource] - PloS one 2017 - e0181081 p. digital
Publication Type: Journal Article
1932-6203
10.1371/journal.pone.0181081 doi
A549 Cells
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Ataxia Telangiectasia Mutated Proteins--genetics
Blotting, Western
Carcinoma, Non-Small-Cell Lung--genetics
Carrier Proteins--genetics
Cisplatin--pharmacology
Cyclin-Dependent Kinase Inhibitor p21--genetics
DNA-Binding Proteins--genetics
Drug Resistance, Neoplasm--drug effects
G2 Phase Cell Cycle Checkpoints--drug effects
Gene Expression Regulation, Neoplastic--drug effects
Heat-Shock Proteins--genetics
Humans
Lung Neoplasms--genetics
Proto-Oncogene Proteins c-mdm2--genetics
Reverse Transcriptase Polymerase Chain Reaction
Tumor Suppressor Protein p53--genetics
Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest. [electronic resource] - PloS one 2017 - e0181081 p. digital
Publication Type: Journal Article
1932-6203
10.1371/journal.pone.0181081 doi
A549 Cells
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Ataxia Telangiectasia Mutated Proteins--genetics
Blotting, Western
Carcinoma, Non-Small-Cell Lung--genetics
Carrier Proteins--genetics
Cisplatin--pharmacology
Cyclin-Dependent Kinase Inhibitor p21--genetics
DNA-Binding Proteins--genetics
Drug Resistance, Neoplasm--drug effects
G2 Phase Cell Cycle Checkpoints--drug effects
Gene Expression Regulation, Neoplastic--drug effects
Heat-Shock Proteins--genetics
Humans
Lung Neoplasms--genetics
Proto-Oncogene Proteins c-mdm2--genetics
Reverse Transcriptase Polymerase Chain Reaction
Tumor Suppressor Protein p53--genetics