Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease.

Schaefer, Natascha

Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience 08 2017 - 7948-7961 p. digital

Publication Type: Journal Article

1529-2401

10.1523/JNEUROSCI.0009-17.2017 doi


Animals
Extracellular Fluid--metabolism
Female
HEK293 Cells
Humans
Ion Channel Gating--physiology
Male
Mice
Mice, 129 Strain
Mice, Inbred C57BL
Mice, Transgenic
Motor Neurons--metabolism
Mutation, Missense--physiology
Protein Structure, Secondary
Receptors, Glycine--chemistry
Severity of Illness Index
Spinal Cord--metabolism
Stiff-Person Syndrome--genetics
Synapses--genetics
Synaptic Transmission--physiology