Hsp90 inhibitor geldanamycin attenuates the cytotoxicity of sunitinib in cardiomyocytes via inhibition of the autophagy pathway.

Kimura, Takayuki

Hsp90 inhibitor geldanamycin attenuates the cytotoxicity of sunitinib in cardiomyocytes via inhibition of the autophagy pathway. [electronic resource] - Toxicology and applied pharmacology 08 2017 - 282-292 p. digital

Publication Type: Journal Article

1096-0333

10.1016/j.taap.2017.06.015 doi


Animals
Antineoplastic Agents--toxicity
Autophagy--drug effects
Autophagy-Related Protein 7--genetics
Autophagy-Related Protein-1 Homolog--genetics
Beclin-1--genetics
Benzoquinones--pharmacology
Cardiotoxicity
Cell Differentiation
Cell Line
Cell Lineage
Cytoprotection
Dose-Response Relationship, Drug
HSP70 Heat-Shock Proteins--genetics
HSP90 Heat-Shock Proteins--antagonists & inhibitors
Humans
Indoles--toxicity
Induced Pluripotent Stem Cells--drug effects
Lactams, Macrocyclic--pharmacology
Myocytes, Cardiac--drug effects
Protein Kinase Inhibitors--toxicity
Pyrroles--toxicity
RNA Interference
Rats
Signal Transduction--drug effects
Sunitinib
Transfection