Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).

Gopalsamy, Ariamala

Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). [electronic resource] - Journal of medicinal chemistry 04 2017 - 3094-3108 p. digital

Publication Type: Journal Article

1520-4804

10.1021/acs.jmedchem.7b00124 doi


Animals
Disease Models, Animal
Drug Design
Endoribonucleases--antagonists & inhibitors
Enzyme Inhibitors--chemistry
HEK293 Cells
Humans
Mice
Molecular Docking Simulation
Muscular Atrophy, Spinal--drug therapy
Quinazolines--chemistry
RNA, Messenger--antagonists & inhibitors
Survival of Motor Neuron 2 Protein