Balanced secretion of anti-CEA × anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity.

Mølgaard, K

Balanced secretion of anti-CEA × anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity. [electronic resource] - Gene therapy 04 2017 - 208-214 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1476-5462

10.1038/gt.2017.3 doi


Antibodies, Bispecific--genetics
CD3 Complex--genetics
Carcinoembryonic Antigen--immunology
Cytotoxicity, Immunologic
Foot-and-Mouth Disease Virus--genetics
Humans
Immunotherapy--methods
Jurkat Cells
Lymphocyte Activation--immunology
Neoplasms--immunology
Peptides--genetics
Single-Chain Antibodies--genetics
T-Lymphocytes--immunology
Tumor Necrosis Factor Receptor Superfamily, Member 7--genetics