CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis.

Raghu, Harini

CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis. [electronic resource] - Annals of the rheumatic diseases May 2017 - 914-922 p. digital

Publication Type: Journal Article

1468-2060

10.1136/annrheumdis-2016-210426 doi


Animals
Cartilage, Articular--pathology
Chemokine CCL2--genetics
Chemokine CCL5--genetics
Chemokines--genetics
Chemotaxis
Fibroblasts--metabolism
Gene Expression
Humans
Indazoles--pharmacology
Leukocyte Count
Macrophages
Male
Mice, Inbred C57BL
Mice, Knockout
Monocytes--physiology
Osteoarthritis--metabolism
Propionates--pharmacology
RNA, Messenger--metabolism
Receptors, CCR2--antagonists & inhibitors
Receptors, CCR5--genetics
Signal Transduction--drug effects
Synovial Fluid--metabolism