Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.

Jian, Jinlong

Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease. [electronic resource] - EBioMedicine Nov 2016 - 212-224 p. digital

Publication Type: Journal Article

2352-3964

10.1016/j.ebiom.2016.10.010 doi


Animals
Cell Line
Disease Models, Animal
Fibroblasts--drug effects
Gaucher Disease--drug therapy
Glucosylceramidase--metabolism
HSP70 Heat-Shock Proteins--genetics
Humans
Intercellular Signaling Peptides and Proteins--genetics
Lysosomal Membrane Proteins--metabolism
Lysosomes--metabolism
Mice
Mice, Knockout
Phenotype
Progranulins
Protein Aggregates
Protein Binding
Recombinant Proteins--pharmacology
Stress, Physiological