Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence.

Wang, Chenyao

Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence. [electronic resource] - The international journal of biochemistry & cell biology 11 2016 - 132-142 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1878-5875

10.1016/j.biocel.2016.09.029 doi


Cell Line, Tumor
Cell Proliferation
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p21--metabolism
Gene Expression Regulation, Neoplastic
Humans
Inhibitor of Differentiation Proteins--metabolism
Melanoma--metabolism
Microphthalmia-Associated Transcription Factor--metabolism
Phosphorylation
Proteolysis
Proto-Oncogene Proteins c-akt--metabolism
Tumor Suppressor Protein p53--metabolism