Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis.

Dosoki, Heba

Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis. [electronic resource] - Experimental dermatology 01 2017 - 73-81 p. digital

Publication Type: Journal Article

1600-0625

10.1111/exd.13180 doi


Actins--genetics
Adult
Animals
Cells, Cultured
Collagen Type I--genetics
Collagen Type I, alpha 1 Chain
Computer Simulation
Cytokines--genetics
Disease Models, Animal
Enzyme Inhibitors--pharmacology
Female
Fibroblasts--enzymology
Fibronectins
Fibrosis
Gene Expression--drug effects
Gene Expression Profiling
Gene Silencing
Humans
Infant, Newborn
Isoenzymes--genetics
Male
Mice
Middle Aged
Multienzyme Complexes--metabolism
Myofibroblasts
NADH, NADPH Oxidoreductases--metabolism
NADPH Oxidase 1--genetics
NADPH Oxidase 2--genetics
NADPH Oxidase 4--genetics
Onium Compounds--pharmacology
Primary Cell Culture
RNA, Messenger--metabolism
Scleroderma, Systemic--chemically induced
Skin--enzymology
Transforming Growth Factor beta--pharmacology
Young Adult