The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs.
Doñas, Cristian
The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs. [electronic resource] - Journal of autoimmunity Dec 2016 - 105-117 p. digital
Publication Type: Journal Article
1095-9157
10.1016/j.jaut.2016.07.011 doi
Adoptive Transfer
Animals
Antigens, CD--immunology
B7-1 Antigen--immunology
B7-2 Antigen--immunology
Benzazepines--pharmacology
Blotting, Western
CD4-Positive T-Lymphocytes--immunology
Cytokines--genetics
Dendritic Cells--drug effects
Encephalomyelitis, Autoimmune, Experimental--genetics
Gene Expression--drug effects
Immune Tolerance--genetics
Inflammation Mediators--immunology
Integrin alpha Chains--immunology
Jumonji Domain-Containing Histone Demethylases--antagonists & inhibitors
Mice, Inbred C57BL
Mice, Transgenic
Phenotype
Pyrimidines--pharmacology
Reverse Transcriptase Polymerase Chain Reaction
Transforming Growth Factor beta1--immunology
The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs. [electronic resource] - Journal of autoimmunity Dec 2016 - 105-117 p. digital
Publication Type: Journal Article
1095-9157
10.1016/j.jaut.2016.07.011 doi
Adoptive Transfer
Animals
Antigens, CD--immunology
B7-1 Antigen--immunology
B7-2 Antigen--immunology
Benzazepines--pharmacology
Blotting, Western
CD4-Positive T-Lymphocytes--immunology
Cytokines--genetics
Dendritic Cells--drug effects
Encephalomyelitis, Autoimmune, Experimental--genetics
Gene Expression--drug effects
Immune Tolerance--genetics
Inflammation Mediators--immunology
Integrin alpha Chains--immunology
Jumonji Domain-Containing Histone Demethylases--antagonists & inhibitors
Mice, Inbred C57BL
Mice, Transgenic
Phenotype
Pyrimidines--pharmacology
Reverse Transcriptase Polymerase Chain Reaction
Transforming Growth Factor beta1--immunology