Insulin-like growth factor 1 rescues R28 retinal neurons from apoptotic death through ERK-mediated BimEL phosphorylation independent of Akt.
Kong, Dejuan
Insulin-like growth factor 1 rescues R28 retinal neurons from apoptotic death through ERK-mediated BimEL phosphorylation independent of Akt. [electronic resource] - Experimental eye research 10 2016 - 82-95 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
1096-0007
10.1016/j.exer.2016.08.002 doi
Animals
Apoptosis--drug effects
Blotting, Western
Cell Line
Cell Survival
Disease Models, Animal
Gene Expression Regulation
Insulin-Like Growth Factor I--pharmacology
Microscopy, Confocal
Mitogen-Activated Protein Kinase 3--biosynthesis
Phosphorylation
Proto-Oncogene Proteins c-akt--biosynthesis
RNA--genetics
Rats
Rats, Sprague-Dawley
Real-Time Polymerase Chain Reaction
Retinal Ganglion Cells--metabolism
Signal Transduction
Insulin-like growth factor 1 rescues R28 retinal neurons from apoptotic death through ERK-mediated BimEL phosphorylation independent of Akt. [electronic resource] - Experimental eye research 10 2016 - 82-95 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
1096-0007
10.1016/j.exer.2016.08.002 doi
Animals
Apoptosis--drug effects
Blotting, Western
Cell Line
Cell Survival
Disease Models, Animal
Gene Expression Regulation
Insulin-Like Growth Factor I--pharmacology
Microscopy, Confocal
Mitogen-Activated Protein Kinase 3--biosynthesis
Phosphorylation
Proto-Oncogene Proteins c-akt--biosynthesis
RNA--genetics
Rats
Rats, Sprague-Dawley
Real-Time Polymerase Chain Reaction
Retinal Ganglion Cells--metabolism
Signal Transduction