Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs.

Berte, Nancy

Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs. [electronic resource] - Molecular cancer therapeutics 11 2016 - 2665-2678 p. digital

Publication Type: Journal Article

1538-8514

10.1158/1535-7163.MCT-16-0176 doi


Animals
Antineoplastic Agents, Alkylating--pharmacology
Apoptosis--drug effects
Cell Line, Tumor
Cell Survival--drug effects
Chromosome Aberrations--drug effects
DNA Damage
DNA Modification Methylases--metabolism
DNA Repair
DNA Repair Enzymes--metabolism
DNA Replication--drug effects
DNA-Binding Proteins--metabolism
Disease Models, Animal
Glioblastoma--drug therapy
Homologous Recombination--drug effects
Humans
Lomustine--pharmacology
MRE11 Homologue Protein
Mice
Rad51 Recombinase--metabolism
Tumor Suppressor Proteins--metabolism
Xenograft Model Antitumor Assays