The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL‑induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells.

Nathwani, Seema-Maria

The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL‑induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells. [electronic resource] - International journal of oncology Jul 2016 - 74-88 p. digital

Publication Type: Journal Article

1791-2423

10.3892/ijo.2016.3518 doi


Apoptosis--drug effects
CASP8 and FADD-Like Apoptosis Regulating Protein--biosynthesis
Caspase 8--biosynthesis
Cell Line, Tumor
Drug Resistance, Neoplasm--genetics
Drug Synergism
Gene Expression Regulation, Leukemic--drug effects
Humans
Myeloid Cell Leukemia Sequence 1 Protein--biosynthesis
Oxazepines--administration & dosage
Phosphatidylinositol 3-Kinases--genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma--drug therapy
Pyrroles--administration & dosage
Receptors, TNF-Related Apoptosis-Inducing Ligand--biosynthesis
Signal Transduction--drug effects
TNF-Related Apoptosis-Inducing Ligand--administration & dosage