Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation.

Severson, Tesa M

Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation. [electronic resource] - Oncotarget Jun 2016 - 33901-18 p. digital

Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial

1949-2553

10.18632/oncotarget.8983 doi


Adult
Aged
Biomarkers, Tumor--genetics
Breast Neoplasms--drug therapy
Cell Proliferation--drug effects
Chemotherapy, Adjuvant
Chromatin--genetics
DNA Copy Number Variations
Estrogen Receptor alpha--drug effects
Female
Gene Dosage
Gene Expression Profiling--methods
Gene Expression Regulation, Neoplastic--drug effects
Hepatocyte Nuclear Factor 3-alpha--genetics
Humans
MCF-7 Cells
Middle Aged
Neoadjuvant Therapy
Netherlands
Patient Selection
Precision Medicine
Predictive Value of Tests
Protein Binding
Selective Estrogen Receptor Modulators--administration & dosage
Tamoxifen--administration & dosage
Time Factors
Transcription, Genetic
Transcriptome--drug effects
Treatment Outcome