Binding of Released Bim to Mcl-1 is a Mechanism of Intrinsic Resistance to ABT-199 which can be Overcome by Combination with Daunorubicin or Cytarabine in AML Cells.
Niu, Xiaojia
Binding of Released Bim to Mcl-1 is a Mechanism of Intrinsic Resistance to ABT-199 which can be Overcome by Combination with Daunorubicin or Cytarabine in AML Cells. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Sep 2016 - 4440-51 p. digital
Publication Type: Journal Article
1557-3265
10.1158/1078-0432.CCR-15-3057 doi
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Bcl-2-Like Protein 11--metabolism
Bridged Bicyclo Compounds, Heterocyclic--pharmacology
Cell Line, Tumor
Cytarabine--pharmacology
Daunorubicin--pharmacology
Drug Resistance, Neoplasm
Drug Synergism
Humans
Leukemia, Myeloid, Acute--drug therapy
Myeloid Cell Leukemia Sequence 1 Protein--metabolism
Protein Stability--drug effects
Sulfonamides--pharmacology
Binding of Released Bim to Mcl-1 is a Mechanism of Intrinsic Resistance to ABT-199 which can be Overcome by Combination with Daunorubicin or Cytarabine in AML Cells. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Sep 2016 - 4440-51 p. digital
Publication Type: Journal Article
1557-3265
10.1158/1078-0432.CCR-15-3057 doi
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Bcl-2-Like Protein 11--metabolism
Bridged Bicyclo Compounds, Heterocyclic--pharmacology
Cell Line, Tumor
Cytarabine--pharmacology
Daunorubicin--pharmacology
Drug Resistance, Neoplasm
Drug Synergism
Humans
Leukemia, Myeloid, Acute--drug therapy
Myeloid Cell Leukemia Sequence 1 Protein--metabolism
Protein Stability--drug effects
Sulfonamides--pharmacology