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Expression of GRP78, Master Regulator of the Unfolded Protein Response, Increases Chemoresistance in Pancreatic Ductal Adenocarcinoma.

Gifford, Jenifer B

Expression of GRP78, Master Regulator of the Unfolded Protein Response, Increases Chemoresistance in Pancreatic Ductal Adenocarcinoma. [electronic resource] - Molecular cancer therapeutics 05 2016 - 1043-52 p. digital

Publication Type: Journal Article

ISSN: 1538-8514

Standard No.: 10.1158/1535-7163.MCT-15-0774 doi

Subjects--Topical Terms:
Adenocarcinoma--drug therapy
Adult
Aged
Aged, 80 and over
Animals
Antineoplastic Agents--pharmacology
Carcinoma, Pancreatic Ductal--drug therapy
Cell Line, Tumor
Deoxycytidine--analogs & derivatives
Disease Models, Animal
Drug Resistance, Neoplasm--genetics
Drug Synergism
Endoplasmic Reticulum Chaperone BiP
Endoplasmic Reticulum Stress--genetics
Female
Gene Expression
Gene Expression Profiling
Gene Expression Regulation, Neoplastic--drug effects
Gene Knockdown Techniques
Heat-Shock Proteins--genetics
Humans
Immunohistochemistry
Male
Middle Aged
Proto-Oncogene Proteins c-akt--genetics
Survival Analysis
Unfolded Protein Response
Xenograft Model Antitumor Assays
Gemcitabine