Comparative effects of azapropazone on cellular events at inflamed sites. Influence on joint pathology in arthritic rats, leucocyte superoxide and eicosanoid production, platelet aggregation, synthesis of cartilage proteoglycans, synovial production and actions of interleukin-1 in cartilage resorption correlated with drug uptake into cartilage in-vitro.

Rainsford, K D

Comparative effects of azapropazone on cellular events at inflamed sites. Influence on joint pathology in arthritic rats, leucocyte superoxide and eicosanoid production, platelet aggregation, synthesis of cartilage proteoglycans, synovial production and actions of interleukin-1 in cartilage resorption correlated with drug uptake into cartilage in-vitro. [electronic resource] - The Journal of pharmacy and pharmacology May 1989 - 322-30 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0022-3573

10.1111/j.2042-7158.1989.tb06465.x doi


Animals
Apazone--pharmacokinetics
Arthritis--physiopathology
Arthritis, Experimental--metabolism
Cartilage, Articular--metabolism
Cattle
Female
In Vitro Techniques
Interleukin-1--metabolism
Leukocytes--metabolism
Neutrophils--drug effects
Platelet Aggregation--drug effects
Prostaglandins--biosynthesis
Proteoglycans--metabolism
Rats
Rats, Inbred Strains
Superoxides
Swine
Synovial Membrane--drug effects
Triazines--pharmacology