Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction.

Nishikawa, Joy L

Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction. [electronic resource] - Nature Feb 2016 - 485-9 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1476-4687

10.1038/nature16963 doi


Animals
Antifungal Agents--pharmacology
Binding Sites--drug effects
Candida glabrata--drug effects
Candidiasis--drug therapy
DNA-Binding Proteins--genetics
Drug Resistance, Fungal--drug effects
Drug Resistance, Multiple, Fungal--drug effects
Fluconazole--pharmacology
Fungal Proteins--metabolism
Gene Expression Regulation, Fungal--drug effects
Hydrazines--pharmacokinetics
Ketoconazole--pharmacology
Mediator Complex--chemistry
Mice
Models, Molecular
Nuclear Magnetic Resonance, Biomolecular
Protein Binding--drug effects
Protein Structure, Tertiary
Saccharomyces cerevisiae Proteins--chemistry
Thiourea--analogs & derivatives
Trans-Activators--chemistry
Transcription Factors--genetics
Transcriptional Activation--drug effects
Up-Regulation--drug effects