iRGD-targeted delivery of a pro-apoptotic peptide activated by cathepsin B inhibits tumor growth and metastasis in mice.

Qifan, Wang

iRGD-targeted delivery of a pro-apoptotic peptide activated by cathepsin B inhibits tumor growth and metastasis in mice. [electronic resource] - Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Aug 2016 - 10643-52 p. digital

Publication Type: Journal Article

1423-0380

10.1007/s13277-016-4961-x doi


Activation, Metabolic
Amino Acid Sequence
Animals
Antineoplastic Agents--administration & dosage
Apoptosis--drug effects
Breast Neoplasms--pathology
Cathepsin B--metabolism
Cell Division--drug effects
Cell Line, Tumor
Cell-Penetrating Peptides--administration & dosage
Drug Carriers--administration & dosage
Drug Screening Assays, Antitumor
Female
Humans
Mammary Neoplasms, Experimental--drug therapy
Melanoma, Experimental--pathology
Mice
Mice, Inbred BALB C
Mitochondria--drug effects
Neoplasm Metastasis
Neuropilin-1--physiology
Oligopeptides--administration & dosage
Prodrugs--administration & dosage
fas Receptor--physiology