Structure- and function-based design of Plasmodium-selective proteasome inhibitors.

Li, Hao

Structure- and function-based design of Plasmodium-selective proteasome inhibitors. [electronic resource] - Nature Feb 2016 - 233-6 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1476-4687

10.1038/nature16936 doi


Animals
Antimalarials--adverse effects
Artemisinins--pharmacology
Catalytic Domain
Cryoelectron Microscopy
Dose-Response Relationship, Drug
Drug Design
Drug Resistance
Drug Synergism
Enzyme Activation
Female
Humans
Mice
Mice, Inbred BALB C
Models, Molecular
Plasmodium--drug effects
Plasmodium chabaudi--drug effects
Plasmodium falciparum--drug effects
Proteasome Endopeptidase Complex--chemistry
Proteasome Inhibitors--adverse effects
Protein Subunits--antagonists & inhibitors
Species Specificity
Substrate Specificity--drug effects