Pharmacologically induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset.

Feng, Zhihua

Pharmacologically induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset. [electronic resource] - Human molecular genetics Mar 2016 - 964-75 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1460-2083

10.1093/hmg/ddv629 doi


Adolescent
Adult
Age of Onset
Animals
Dependovirus--genetics
Disease Models, Animal
Follistatin--pharmacology
Gene Deletion
Genetic Vectors--chemistry
Humans
Immunologic Factors--pharmacology
Mice
Motor Neurons--drug effects
Muscular Atrophy, Spinal--drug therapy
Myostatin--antagonists & inhibitors
Phenotype
RNA Splicing--drug effects
Survival of Motor Neuron 1 Protein--genetics
Survival of Motor Neuron 2 Protein--agonists