IL-4 administration exerts preventive effects via suppression of underlying inflammation and TNF-α-induced apoptosis in steroid-induced osteonecrosis.
Wu, X
IL-4 administration exerts preventive effects via suppression of underlying inflammation and TNF-α-induced apoptosis in steroid-induced osteonecrosis. [electronic resource] - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA May 2016 - 1827-37 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1433-2965
10.1007/s00198-015-3474-6 doi
Animals
Anti-Inflammatory Agents, Non-Steroidal--pharmacology
Caspase 3--metabolism
Cells, Cultured
Disease Models, Animal
Drug Evaluation, Preclinical--methods
Glucocorticoids
Inflammation--drug therapy
Interleukin-4--pharmacology
Macrophages--drug effects
Methylprednisolone
Mice, Inbred BALB C
Osteoclasts--drug effects
Osteonecrosis--chemically induced
Recombinant Proteins--pharmacology
STAT1 Transcription Factor--metabolism
Signal Transduction--drug effects
Tartrate-Resistant Acid Phosphatase--blood
Tumor Necrosis Factor-alpha--antagonists & inhibitors
IL-4 administration exerts preventive effects via suppression of underlying inflammation and TNF-α-induced apoptosis in steroid-induced osteonecrosis. [electronic resource] - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA May 2016 - 1827-37 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1433-2965
10.1007/s00198-015-3474-6 doi
Animals
Anti-Inflammatory Agents, Non-Steroidal--pharmacology
Caspase 3--metabolism
Cells, Cultured
Disease Models, Animal
Drug Evaluation, Preclinical--methods
Glucocorticoids
Inflammation--drug therapy
Interleukin-4--pharmacology
Macrophages--drug effects
Methylprednisolone
Mice, Inbred BALB C
Osteoclasts--drug effects
Osteonecrosis--chemically induced
Recombinant Proteins--pharmacology
STAT1 Transcription Factor--metabolism
Signal Transduction--drug effects
Tartrate-Resistant Acid Phosphatase--blood
Tumor Necrosis Factor-alpha--antagonists & inhibitors