HDAC inhibition impedes epithelial-mesenchymal plasticity and suppresses metastatic, castration-resistant prostate cancer.
Ruscetti, M
HDAC inhibition impedes epithelial-mesenchymal plasticity and suppresses metastatic, castration-resistant prostate cancer. [electronic resource] - Oncogene 07 2016 - 3781-95 p. digital
Publication Type: Journal Article
1476-5594
10.1038/onc.2015.444 doi
Animals
Blotting, Western
Cell Line, Tumor
Disease Models, Animal
Epithelial-Mesenchymal Transition--drug effects
Gene Expression Profiling--methods
Gene Expression Regulation, Neoplastic--drug effects
Histone Deacetylase Inhibitors--pharmacology
Humans
Hydroxamic Acids--pharmacology
Indoles--pharmacology
Male
Mice, Inbred NOD
Mice, Knockout
Mice, SCID
Mice, Transgenic
Mitogen-Activated Protein Kinases--metabolism
Neoplasm Metastasis
PTEN Phosphohydrolase--genetics
Panobinostat
Phosphatidylinositol 3-Kinases--metabolism
Prostatic Neoplasms, Castration-Resistant--drug therapy
Proto-Oncogene Proteins c-akt--metabolism
Proto-Oncogene Proteins p21(ras)--genetics
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction--drug effects
HDAC inhibition impedes epithelial-mesenchymal plasticity and suppresses metastatic, castration-resistant prostate cancer. [electronic resource] - Oncogene 07 2016 - 3781-95 p. digital
Publication Type: Journal Article
1476-5594
10.1038/onc.2015.444 doi
Animals
Blotting, Western
Cell Line, Tumor
Disease Models, Animal
Epithelial-Mesenchymal Transition--drug effects
Gene Expression Profiling--methods
Gene Expression Regulation, Neoplastic--drug effects
Histone Deacetylase Inhibitors--pharmacology
Humans
Hydroxamic Acids--pharmacology
Indoles--pharmacology
Male
Mice, Inbred NOD
Mice, Knockout
Mice, SCID
Mice, Transgenic
Mitogen-Activated Protein Kinases--metabolism
Neoplasm Metastasis
PTEN Phosphohydrolase--genetics
Panobinostat
Phosphatidylinositol 3-Kinases--metabolism
Prostatic Neoplasms, Castration-Resistant--drug therapy
Proto-Oncogene Proteins c-akt--metabolism
Proto-Oncogene Proteins p21(ras)--genetics
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction--drug effects