Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents.
Shaik, Jeelan Basha
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents. [electronic resource] - European journal of medicinal chemistry Jan 2016 - 219-32 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1768-3254
10.1016/j.ejmech.2015.10.046 doi
Acetylcholinesterase--chemistry
Alzheimer Disease--drug therapy
Animals
Antioxidants--chemistry
Binding Sites
Butyrylcholinesterase--metabolism
Chemistry Techniques, Synthetic
Cholinesterase Inhibitors--chemistry
Computer Simulation
Coumarins--chemical synthesis
Drug Evaluation, Preclinical--methods
Galantamine--pharmacology
Humans
Hydrogen Peroxide--toxicity
Male
Mice, Inbred BALB C
Models, Molecular
Neuroprotective Agents--chemical synthesis
Neurotoxicity Syndromes--etiology
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents. [electronic resource] - European journal of medicinal chemistry Jan 2016 - 219-32 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1768-3254
10.1016/j.ejmech.2015.10.046 doi
Acetylcholinesterase--chemistry
Alzheimer Disease--drug therapy
Animals
Antioxidants--chemistry
Binding Sites
Butyrylcholinesterase--metabolism
Chemistry Techniques, Synthetic
Cholinesterase Inhibitors--chemistry
Computer Simulation
Coumarins--chemical synthesis
Drug Evaluation, Preclinical--methods
Galantamine--pharmacology
Humans
Hydrogen Peroxide--toxicity
Male
Mice, Inbred BALB C
Models, Molecular
Neuroprotective Agents--chemical synthesis
Neurotoxicity Syndromes--etiology