The plasticizer BBP selectively inhibits epigenetic regulator sirtuins.

Zhang, Jian

The plasticizer BBP selectively inhibits epigenetic regulator sirtuins. [electronic resource] - Toxicology Dec 2015 - 130-41 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1879-3185

10.1016/j.tox.2015.10.004 doi


Binding Sites
Crystallography
Dose-Response Relationship, Drug
Endocrine Disruptors--metabolism
Epigenesis, Genetic--drug effects
Gene Expression Regulation
Hep G2 Cells
Hepatocytes--drug effects
Histone Deacetylase Inhibitors--metabolism
Humans
Hydrogen Bonding
Ligands
Mitochondria, Liver--drug effects
Molecular Docking Simulation
NF-E2-Related Factor 2--genetics
Nuclear Respiratory Factor 1--genetics
Organelle Biogenesis
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Phthalic Acids--metabolism
Plasticizers--metabolism
Protein Binding
Protein Conformation
RNA Interference
Reactive Oxygen Species--metabolism
Sirtuin 1--antagonists & inhibitors
Sirtuin 3--antagonists & inhibitors
Transcription Factors--genetics
Transfection