Inactivation of TGFβ receptor II signalling in pancreatic epithelial cells promotes acinar cell proliferation, acinar-to-ductal metaplasia and fibrosis during pancreatitis.

Grabliauskaite, Kamile

Inactivation of TGFβ receptor II signalling in pancreatic epithelial cells promotes acinar cell proliferation, acinar-to-ductal metaplasia and fibrosis during pancreatitis. [electronic resource] - The Journal of pathology Feb 2016 - 434-45 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1096-9896

10.1002/path.4666 doi


Acinar Cells--pathology
Amylases--metabolism
Animals
Carcinoma, Pancreatic Ductal--pathology
Cell Cycle Checkpoints--physiology
Cell Proliferation--physiology
Cell Transformation, Neoplastic--pathology
Cells, Cultured
Ceruletide--toxicity
Epithelial Cells--pathology
Fibrosis--pathology
Irritants--toxicity
Lipase--metabolism
Male
Metaplasia--pathology
Mice, Knockout
Mice, Transgenic
Pancreas--enzymology
Pancreatic Neoplasms--pathology
Pancreatitis--enzymology
Protein Serine-Threonine Kinases--antagonists & inhibitors
Receptor, Transforming Growth Factor-beta Type II
Receptors, Transforming Growth Factor beta--antagonists & inhibitors